Pharmacological studies on melanocyte-stimulating hormone

Y2-Melanocyte-Stimulating Hormone

Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...

-Melanocyte-Stimulating Hormone Inhibits Allergic Airway Inflammation

Isolation of melanocyte-stimulating hormone from hog pituitary gland.

The present communication is concerned with two substances possessing melanocyte-stimulating hormone (MSH) activity, ar-MSH and /3-MSH, found in hog pituitary gland. The main component, o(-MSH, was isolated by a four-step process consisting of solvent extraction and fractional precipitation, oxycellulose adsorption, counter-current distribution, and paper electrophoresis. a-MSH has been found t...

N , 0 - Diacetylserinel a - Melanocyte - stimulating Hormone , a Naturally Occurring

When aqueous extract of bovine pituitary gland was fractionated by high pressure liquid chromatography (HPLC), the effluent contained a prominent peak of melanotropic activity which did not correspond to amelanocyte-stimulating hormone (MSH), /?-MSH, adrenocorticotropic hormone, or p lipotropin. The novel factor (labeled “post-a-MSH”), responsible for onethird of the melanotropic activity in th...